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The cycle churns quickly. We’re already counting down the minutes until the start of Week 6. Trevor Siemian returns to the fray for Denver as they battle the 1-4, snake-bitten Chargers. Can Philip Rivers solve the Denver defense?

We also see Colin Kaepernick back on the field for the 49ers in Buffalo. Is the Rex resurgence for real in Buffalo? (And does this game really serve as a true test?)

Let’s get into the rankings. I’ll update throughout the weekend as injuries note proliferate.